No, when following label directions or as directed by a healthcare professional. Argyria can occur after a lifetime exposure to all forms of silver exceeding 10 grams for the average adult according to the World Health Organization. The most dramatic symptom of argyria is the skin becoming blue or bluish-gray colored. Argyria may be found as generalized argyria or local argyria. Argyrosis is the corresponding condition related to the eye. Argentyn 23 Bio-Active Silver Hydrosol is free of proteins, salts, and other compounds and therefore poses no health hazard when used as directed.* However other colloidal silvers may contain these impurities therefore increasing the risk of causing argyria. Products with high parts per million (PPM) concentrations should be avoided as those products greatly exceed the EPA oral Daily Reference Dose (RfD)† for silver of 350 mcg (micrograms). Argentyn 23 Bio-Active Silver Hydrosol is the only professional silver supplement to have received a statement of safety from Dr. Dana Flavin; Founder and Executive Director; former Science Assistant to the Associate Bureau Director, Division of Toxicology, US FDA, Washington DC.